Bakery and catering company Peyton and Byrne has gone into administration following the loss of contracts at London’s Kew Gardens and the British Library.Peyton and Byrne operates a number of stand-alone bakeries, as well as restaurants. The bakery business has been sold as a separate entity to Peyton and Byrne Bakeries Limited, a new business owned by the Peyton family.There are no redundancies expected of the company’s 440 existing employees, and most of the assets and the majority of the business relating to Peyton and Byrne’s five existing public catering contracts have been sold as part of a pre-packaged sale to foodservice company Sodexo.These contracts will be operated by Sodexo Sports & Leisure, Sodexo’s catering and hospitality partner for sporting venues, major events and visitor attractions in the UK and Ireland.Chris Bray, chief executive of Sports & Leisure, Sodexo UK & Ireland, said: “We are bringing together our resources, talent and expertise to develop an attractive customer experience that will deliver greater value to all our clients.”Earlier this month it was reported the company had appointed Deloitte to explore “strategic options for the future”.Peyton and Byrne co-founder and owner Oliver Peyton said: “I am excited about this opportunity which is good news for the future of the Peyton and Byrne brand and Sodexo.”In December 2012 the Business Growth Fund (BGF) invested £6.3m into the business, which was aimed at expanding the bakery chain. But two years later the company ended its catering contracts after just a year at the Brighton Dome and Brighton’s Royal Pavilion.In 2014 Peyton invested £1m in a new central bakery, and then in 2015, the contract that Peyton and Byrne held with London’s National Gallery was extended by eight years in a deal worth £36m.
Harvard researchers have identified nine genetic variants that dramatically increase the risk of developing type 2 diabetes, adding to our knowledge of the disease’s underpinnings and providing a glimpse of its vast genetic diversity.Amit Majithia, instructor in medicine at Harvard Medical School (HMS) and at Harvard-affiliated Massachusetts General Hospital and a researcher at the Broad Institute of MIT and Harvard, said the variants increase the risk of developing type 2 diabetes sevenfold, but are very rare in the population, found in just one in 1,000 individuals.As significant, Majithia said, is the glimpse of genetic diversity in the single gene studied, called PPARG, which has been known to be associated with diabetes risk for 20 years.Despite the scientific familiarity with the gene, the project’s scan of the genomes of 20,000 people from various international populations revealed 53 mutations, only four of which had been previously described. Further experimentation showed that nine of the 49 remaining mutations caused changes in key proteins that increased the risk of type 2 diabetes.“These rare mutations are only seen in one in 1,000 individuals, but the effect on the individual is very strong because they increase risk by 700 percent,” Majithia said.Majithia believes that the current research has uncovered just the tip of the iceberg with respect to mutations in this gene aloneThe gene, which regulates the development of fat cells, encodes a protein made up of 500 amino acids. With 19 possible amino acids that could be plugged in at each position, there are nearly 10,000 possible mutations, Majithia said, making it highly likely that there are additional mutations — possibly many of them — that affect diabetes risk.The work, published recently in the Proceedings of the National Academy of Sciences, was conducted by a team led by Majithia and David Altshuler, HMS genetics professor and the paper’s senior author. The team included researchers from the Broad, MGH, HMS, Harvard-affiliated Beth Israel Deaconess Medical Center, and the Massachusetts Institute of Technology.The work, Majithia said, began as an effort to understand the role the PPARG gene plays in diabetes. A mutation had been found previously that decreased the risk of type 2 diabetes by 20 percent. On the other hand, rare, familial mutations in the gene had been implicated in a severe malfunction in the development of fat cells and an increased risk of diabetes.The work also highlighted shortcomings in emerging computer-based methods of analyzing the risk presented by genetic mutations, Majithia said. As part of the work, the researchers applied computer algorithms to the 49 new mutations they found and identified them as either benign or damaging. On investigating further, the mutations classified as damaging by the computational algorithms did not show an increased risk of type 2 diabetes.That sent Majithia and colleagues to the lab to examine the mutations one by one, which revealed the nine harmful variants.Majithia plans to continue work to develop methods that can reveal which mutations in PPARG are harmful, in hopes of creating a comprehensive catalog of potentially harmful mutations that clinicians can consult when patients are tested for diabetes risk.“If there are ways to test every possible mutation up front, you can just look up the consequence of any mutation that may be found in the future,” Majithia said.
Sergio Ramos Ramos said suggestions he intentionally played for the yellow card “hurts”, tweeting “I have not forced the card”.Earlier Ramos had told reporters he would “be lying if I said I didn’t force [the booking]”.On Thursday, Uefa said: “A disciplinary inquiry has been opened in connection with the statements made by Real Madrid player Sergio Ramos.”The Spain international was making his 600th appearance for Los Blancos and his side secured a first-leg advantage through Marco Asensio’s goal two minutes before the controversial booking.Pundit Martin Keown said it was “very obvious” Ramos was looking to pick up a third booking in the competition to be banned for the second leg – a suspension at this stage greatly reduces the risk of missing a match later in the competition with all bookings wiped following the quarter-final stage.“In a game there are many tensions, many sensations and many pulsations,” Ramos tweeted. “You have to make decisions in seconds. The best of today is the result. The worst, not being able to be with my team-mates for a game.”Ramos’ team-mate Dani Carvajal received a two-game ban from Uefa when he was judged to have been booked on purpose in the final minute of a 6-0 win over Apoel Nicosia in last season’s tournament.Ramos and former Real midfielder Xabi Alonso were both booked late on in a 3-0 quarter-final first-leg victory over Galatasaray in 2013.Both players were also criticised in 2010, when they were booked and sent off in the final five minutes of a group game with Ajax, meaning they missed the next fixture, with Real already assured of progress to the knockout stage.Share this:FacebookRedditTwitterPrintPinterestEmailWhatsAppSkypeLinkedInTumblrPocketTelegram UEFA is investigating comments from Real Madrid defender Sergio Ramos after it was suggested he was booked on purpose late in Wednesday’s Champions League last-16 first leg at Ajax.Ramos fouled Kasper Dolberg in the 89th minute with Real leading 2-1, earning a suspension for the second leg.A player who purposely obtains a booking can be banned for two games.
A small sailing boat has drifted on to the shore on Mulroy Bay.Reader Patrick McGinley sent us this picture this evening.“It’s in need of rescuing before the weather changes,” he said. “Perhaps some DD readers knows the owner?”Over to you! ANYONE LOSE A BOAT? was last modified: October 24th, 2013 by John2Share this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window) Tags:ANYONE LOSE A BOAT?